Approaches to understanding COVID-19 and its neurological associations
Beghi E, Michael BD, Solomon T, Westenberg E, Winkler AS, COVID-19 Neuro Research Coalition
Ann Neurol. 2021 Apr 9;89(6):1059–1067Abstract:
There is an accumulating volume of research into neurological manifestations of COVID-19. However, inconsistent study designs, inadequate controls, poorly-validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the WHO, has reviewed reports of COVID-19 neurological complications and harmonised clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of SARS-CoV2 infection and neurological complications, with standardised forms for pooled data analyses that non-specialists can use, including in low-income settings.
